| 产品名称 | Synthelis | S052 | Active regulator of SIRT1 |
|---|---|
| 目录号 | S052 |
| 别名 | AROS |
| 外观 | 见COA |
| 分子量 | N/A |
| CAS | N/A |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
| 目录号 | 规格 | 价格 | 库存状态 | |
| S052 | 10µg, 20µg ,100 µg , 200 µg, 500 µg,bulk | 咨询 | 咨询 |
Synthelis | S052 | Active regulator of SIRT1
品名：Active regulator of SIRT1(AROS)
货号：S052
规格：10µg, 20µg ,100 µg , 200 µg, 500 µg,bulk
品牌：Synthelis
产品描述
AROS is a direct active regulator of SIRT1, an NAD+-dependent deacetylase. The binding of AROS to the deacetylase upregulate SIRT1. AROS localizes in the nucleus and the cytoplasmic ribosomes. The nuclear protein AROS (also termed 40S ribosomal protein S19-binding protein 1) enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity. Depletion of AROS enhances p21 expression and increases both the G0/G1 population and apoptosis in response to DNA damage, whereas AROS overexpression improves cell survival.
| Protein | Active regulator of SIRT1 |
| Origin | Human |
| Format | Proteoliposome |
| Molecular weight | 15,4 kDa |
| Application | Screening & display technologies,Structural biology |
