| 产品名称 | Synthelis | S069 | Stromal cell-derived factor 1 |
|---|---|
| 目录号 | S069 |
| 别名 | SDF1a |
| 外观 | 见COA |
| 分子量 | N/A |
| CAS | N/A |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
| 目录号 | 规格 | 价格 | 库存状态 | |
| S069 | 10 µg, 50 µg ,100 µg | 咨询 | 咨询 |
Synthelis | S069 | Stromal cell-derived factor 1
品名：Stromal cell-derived factor 1(SDF1a)
货号：S069
规格：10 µg, 50 µg ,100 µg
品牌：Synthelis
产品描述
SDF-1α is a chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. SDF-1 α activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1α acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. SDF-1α stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase.
| Protein | Stromal cell-derived factor 1 |
| Origin | Human |
| Format | Soluble |
| Molecular weight | 10.7 kDa |
| Application | Drug screening & discovery, antibody development, structural biology |
