| 产品名称 | Quartett C-T003/P-T003 | TRPS1 (QR099) |
|---|---|
| 目录号 | C-T003/P-T003 |
| 别名 | TRPS1 |
| 外观 | 见COA |
| 分子量 | |
| CAS | |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
Quartett C-C031/P-C031 | CD31 (QR034)
品名：TRPS1 (QR099) | Recombinant monoclonal rabbit antibody
货号：C-T003/P-T003
品牌：Quartett
规格：0.1 ml; 0.5 ml; 1 ml; 3 ml; 7 ml; 15 ml
产品描述
| Application | IHC (FFPE) | Host | Rabbit |
| Subclass | IgG | Dilution range | 1:100 – 1:200 |
| Cellular localization | Nucleus | Control | Breast, Breast Carcinoma |
| Immunogen | Synthetic peptide from human TRPS1 | ||
TRPS1, named for its association with the autosomal dominant genetic disorder TRPS1, has been identified as a crucial modulator in the mesenchymal-to-epithelial transition during the development and differentiation of various tissues, including cartilage, bone, kidney, and hair follicles. Recently, TRPS1 was identified as a novel GATA transcription factor that acts as an essential regulator of the growth and differentiation of normal breast epithelial cells and may be involved in breast cancer development. A recent study showed that TRPS1, which is highly expressed in triple-negative breast cancer (TNBC), is significantly more highly expressed than GATA3 in metaplastic (85% vs. 21%) and non-metaplastic (86% vs. 51%) TNBC. Among non-breast tumors, TRPS1 is expressed only in some cases of lung squamous cell carcinoma, urothelial carcinoma (<2%), and ovarian adenocarcinoma. Therefore, TRPS1 has been shown to be a highly specific and sensitive marker for all types of breast cancer, especially TNBC.
