| 产品名称 | Quartett C-P002/P-P002 | PD-1 (QR002) |
|---|---|
| 目录号 | C-P002/P-P002 |
| 别名 | PD-1 |
| 外观 | 见COA |
| 分子量 | |
| CAS | |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
Quartett C-C031/P-C031 | CD31 (QR034)
品名：PD-1 (QR002) | Recombinant monoclonal rabbit antibody
货号：C-P002/P-P002
品牌：Quartett
规格：0.1 ml; 0.5 ml; 1 ml; 3 ml; 7 ml; 15 ml
产品描述
| Application | IHC (FFPE) | Host | Rabbit |
| Subclass | IgG | Dilution range | 1:100 – 1:200 |
| Cellular localization | Cytoplasm, membrane | Control | Tonsil |
| Immunogen | Synthetic peptide from human PD-1 | ||
Programmed death 1 (PD-1; CD279) is a transmembrane protein that acts as a surface receptor for its ligands PD-L1 and PD-L2. PD-1 is primarily expressed on activated T cells, B cells, and myeloid cells. PD-1 is an immune checkpoint and plays a crucial role in downregulating the immune system by inhibiting T cell activation, which in turn reduces autoimmunity. Some tumor cells utilize this mechanism to prevent apoptosis by inhibiting the T cells that target them. PD-1 is a useful marker for angioimmunoblastic lymphomas. Furthermore, increased PD-1 expression has been found to be associated with a poor prognosis in hepatocellular carcinoma and renal cell carcinoma. Treatments targeting PD-1 have shown encouraging results in breast cancer, non-small cell lung cancer (NSCLC), and melanoma.
