| 产品名称 | Quartett C-C024 | Cytokeratin 5/6/ERG (QR027/QR028/ QR040) |
|---|---|
| 目录号 | C-C024 |
| 别名 | Cytokeratin 5/6/ERG |
| 外观 | 见COA |
| 分子量 | |
| CAS | |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
Quartett C-C031/P-C031 | CD31 (QR034)
品名：Cytokeratin 5/6/ERG (QR027/QR028/ QR040) | Recombinant monoclonal rabbit antibody
货号：C-C024
品牌：Quartett
规格：0.1 ml; 0.5 ml; 1 ml; 3 ml; 7 ml; 15 ml
产品描述
| Application | IHC (FFPE) | Host | Rabbit |
| Subclass | IgG | Dilution range | 1:50 – 1:100 |
| Cellular localization | CK5/6: cytoplasm, ERG: nucleus | Control | Mesothelioma, prostate, prostate adenocarcinoma |
| Immunogen | Synthetic peptide from human CK5, CK6 & ERG | ||
Keratins are cytoplasmic intermediate filament proteins expressed by epithelial cells. Cytokeratins 5 and 6 are type II keratins that, in combination, are useful for distinguishing mesotheliomas (positive) from lung carcinomas (negative) or metastatic carcinomas in the pleura (negative). The cocktail detects undifferentiated large cell carcinomas, squamous cell carcinomas, spindle cell squamous cell carcinomas of the skin, malignancies of the prostate and breast, and helps distinguish between ductal hyperplasia of the breast (strong staining) and solid papillary DCIS (negative). ERG, also known as ETS-related genes, is a member of the ETS family of transcription factors that play an important role in cell development, differentiation, proliferation, apoptosis, and tissue remodeling. The antibody labels endothelial cells, lymphocytes, and prostate cancer cells. ERG overexpression is associated with prostate cancer. Furthermore, the TMPRSS2-ERG fusion, caused by translocations and interstitial deletions, is associated with aggressive forms of prostate cancer. The EWS-ERG or EWS-Fli-1 fusion is a feature of Ewing sarcoma.
