| 产品名称 | Peptides EP10025_1 | [beta]-Amyloid (12-28) |
|---|---|
| 目录号 | EP10025_1 |
| 别名 | [beta]-Amyloid (12-28) |
| 外观 | 见COA |
| 分子量 | N/A |
| CAS | N/A |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
| 目录号 | 规格 | 价格 | 库存状态 | |
| EP10025_1 | 1 mg; 5 mg | 咨询 | 咨询 |
Peptides EP10025_1 | [beta]-Amyloid (12-28)
品名：[beta]-Amyloid (12-28)
货号：EP10025_1
规格：1 mg; 5 mg
品牌：Peptides.de
产品描述
Aβ (12-28) represents a binding site for apolipoprotein E (apoE). ApoE is a genetically inherited risk factor for Alzheimer’s disease that promotes aggregation of toxic Aβ. This sequence encompasses a hydrophobic domain (residues 14–21) and a ß-turn (residues 22–28) which place two hydrophobic domains of Aß 14 to 21 and 29 to 40/42 opposite each other, allowing for the assembly of Aß peptides into fibrils. The secondary structure of Aß (12- 28), a neutral peptide, is dominated by a-helix and random coil. The interaction of apoE with residues 12 to 28 of Aß is not just a non-specific hydrophobic interaction but plays a pivotal role in the mechanism of Aß pathology in Alzheimer’s disease (AD). Aß (11-28) and five other fragments enhanced aggregation of full length Aß (1-40). All of the peptides that enhance aggregation contained either residues 17 to 20 or 30 to 35, indicating the importance of these regions for promoting aggregation of full-length Aß.
| Protein | Amyloid-beta precursor protein |
| Species | Human |
| Application | ELISPOT, Flow Cytometry, Western Blotting |
| Indication | Neuroscience |
