| 产品名称 | Peptides LB01819 | VZV (IE63) Peptide Pool |
|---|---|
| 目录号 | LB01819 |
| 别名 | VZV (IE63) Peptide Pool |
| 外观 | 见COA |
| 分子量 | N/A |
| CAS | N/A |
| 溶解度 | |
| 存储条件 | 见COA |
| 保存时间 | 见COA |
| 备注1 | |
| 备注2 |
| 目录号 | 规格 | 价格 | 库存状态 | |
| LB01819 | 15 nmol/peptide | 咨询 | 咨询 |
Peptides LB01819 | VZV (IE63) Peptide Pool
品名：VZV (IE63) Peptide Pool
货号：LB01819
规格：15 nmol/peptide
品牌：Peptides.de
产品描述
Peptide pool of 67 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through Transcriptional transactivator IE63 (UniProt ID: Q77NN7-1) of Varicella-zoster virus (strain Oka vaccine) for T cell assays One unit of the VZV (IE63) Peptide Pool allows the stimulation of 2,5 x 108 cells.The transcriptional transactivator IE63 is a phosphoprotein that is also known as immediate early 63-kDa protein (IE63) and transcriptional regulator ICP22 homolog. In the early stage of a VZV infection, IE63 is primarily expressed in the nucleus of the host cell. It interacts with transcription factors and RNA polymerases such as: GTF2E1 GTF2H2 POLR2A These interactions enable IE63 to regulate the transcription of cellular and viral mRNAs. IE63 modulates the function of the immediate early protein 62 (IE62), which is the most important viral transactivator. By disorganizing specific host promoters, IE63 also helps to suppress the innate immune response to the virus. Additionally, IE63 can interact with host proteins, such as ASF1, altering their ability to bind histones. During latency of the virus, IE63 is mostly localized in the cytoplasm. Read more about the Varicella zoster virus and its proteins in our blog post: "Varicella Zoster Virus: gE, IE-62 and IE-63 essential for Infection"
| Protein | Transcriptional regulator ICP22 homolog |
| Species | Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3) |
| Application | T-cell assays, Immune monitoring, Antigen specific T-cell stimulation, T-cell expansion, Cellular immune response |
| Indication | Infectious disease, Neuroscience |
