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ERBB2/Con17 FISH Probe

ERBB2-CHR17-20-ORGR   20 (40 μL)

ERBB2-CHR17-20-REGR   20 (40 μL)

ERBB2-CHR17-20-GOGR   20 (40 μL)

Brand：Empire Genomics 

Our ERBB2/Control 17 probe is designed to detect ERBB2 amplifications and deletions. The probe comes labeled in orange and green, but can be customized to meet your needs.

Gene Background: ERBB2 is a member of the receptor tyrosine kinase family, a subset of receptor proteins that bind epidermal growth factor (EGF).1 ERBB2 doesn’t have a binding domain itself, but stabilizes the configurations of other receptor proteins, making it easier for EGF to latch on.1 ERBB2 is involved in a lengthy list of important signaling cascades, as EGF is a ubiquitous mitogenic factor that stimulates cell growth in many tissue types.2 ERBB2’s oncogenic effects first came to light in 1987, when it was found to play a major role in breast cancer metastasis.3 The gene remains primarily associated with breast cancer (20-30% of breast cancer patients have amplified ERBB2) but it’s now also considered an important oncogene in uterine, gastric, pancreatic, colorectal and endometrial cancer, among others.

Product Details

SKU                                                                      Test Kits       Buffer

ERBB2-CHR17-20-ORGR  (Standard Design)      20 (40 μL)       200 μL

ERBB2-CHR17-20-REGR                                      20 (40 μL)       200 μL

ERBB2-CHR17-20-GOGR                              20 (40 μL)       200 μL